Walther Straub Institute of Pharmacology and Toxicology
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Gudermann/Breit Lab

Head: Dr. Andreas Breit

deutsche Version

Signaling and pharmacodynamics of G Protein-coupled receptors involved in the central regulation of appetite and energy metabolism

Our laboratory is interested in the signaling events induced by GPCR leading to the regulation of food intake and energy homeostasis in the hypothalamus. To this end, we use distinct murine, hypothalamic cell lines and test their reaction to various neuropeptides (melanocortins, serotonin, bradykinin, NPY) in terms of receptor desensitisation, second messenger production, kinase activation and transcriptional regulation. We use classical methods of pharmacology such as radioligand binding assays and more advanced techniques such as the bioluminescence resonance energy transfer (BRET) approach.

Bachelor:

  • Stephanie Hunger, Biochemistry (Oct 2010 - Feb 2011): “Functional interactions between the human MrgX1 receptor and the TRPV1 ionen channel”

Diplom/Master:

  • Ellen Damm, Chemistry (Apr - Oct 2007): “Dual regulation of TRPV1 activity by SNSR-4”
  • Hans Jürgen Solinski, Human-Biology (Feb - Aug 2008): “Species-specific differences among Mrg receptors in agonist-induced endocytosis”
  • Valeria Besik, Biology (Feb - Dec 2013): “Bradykinin-induced signaling in hypothalamic cell models of the mouse”

PhD:

  • Katharina Wolff, med. (Mar 2007 - Jul 2008): “Ligand-induced endocytosis of melanocortin receptors”
  • Dominik Heeling, med. (Apr 2009 - Sep 2012): “Pertussis toxin-sensitive signalling of α-MSH and AGRP and the melanocortin 4 receptor”

    Doctorates:

  • Evi Glas, rer. nat. (Apr 2013 - Feb 2017): “Anorexigenic signalling of GPCR in hypothalamic cell models”
  • Hans Jürgen Solinski, rer. nat. (Sep 2008 - Jan 2013): “Species specific differences in the regulation and signaling of Mrg receptors of humans, mice and rats”
  • Ellen Damm, rer. nat. (Nov 2007 - May 2012): “α-MSH-induced anorexigenic signaling in murine, hypothalamic cells”

Work in progress:

  • Kathrin Rothe, cand. med. (since Apr 2010): “Morphin-induced gene expression in cell models of primary sensory neurons”
  • Lisa Sophie Lauffer, cand. med. (since Apr 2015): "Serotonininduzierte Signalwege in MC4R/NPYR positiven, hypothalamischen Neuronen"
  • Dennis Faro (since March 2017):

Publications